<?xml version="1.0" encoding="UTF-8"?>
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>Universidad Simon Bolivar</PublisherName>
      <JournalTitle>Revista Ciencia e Innovación en Salud</JournalTitle>
      <PubDate PubStatus="ppublish">
        <Year>2017</Year>
        <Month>Aug</Month>
        <Day>29</Day>
      </PubDate>
    </Journal>
    <ArticleTitle>Disorders of urea cycle: Case report&#13;
</ArticleTitle>
    <FirstPage>44</FirstPage>
    <ELocationID EIdType="doi">10.17081/innosa 4.1.2621</ELocationID>
    <Language>EN</Language>
    <AuthorList>
      <author>
        <FirstName>Adolfo Álvarez  Montañez</FirstName>
        <Email/>
        <AffiliationInfo>
          <Affiliation>Neurólogo Pediatra. Organización Clínica General del Norte. Docente Postgrado Universidad Simón Bolívar. Barranquilla, Colombia.</Affiliation>
        </AffiliationInfo>
      </author>
      <author>
        <FirstName>Carlos Gallón</FirstName>
        <Email/>
        <AffiliationInfo>
          <Affiliation>Pediatra. Organización Clínica General del Norte. Docente Postgrado Universidad Simón Bolívar. Barranquilla, Colombia.</Affiliation>
        </AffiliationInfo>
      </author>
      <author>
        <FirstName>Ornella   Ruiz Pérez</FirstName>
        <Email>ornella.ruiz@hotmail.com</Email>
        <AffiliationInfo>
          <Affiliation>E.S.E. Hospital Niño Jesús de Barranquilla, Colombia</Affiliation>
        </AffiliationInfo>
      </author>
    </AuthorList>
    <Abstract>
      <AbstractText label="SUMMARY">Disorders of urea cycle constitute approximately 50% of severe neonatal hyperammonemia. These disorders are consequence of the deficiency of some of the enzymes involved in the cycle. The prognosis will depend on the degree of enzymatic deficiency, as well as on the timely diagnostic approach and the early treatment.</AbstractText>
      <AbstractText label="METHODS">A neonate with neonatal crisis of difficult management associated to hyperammonemia, which allowed to suspect an inborn error of the metabolism, specifically urea cycle disorder. Timely treatment was initiated, with symptoms control and favorable clinical course.&#13;
</AbstractText>
      <AbstractText label="RESULTS"/>
      <AbstractText label="DISCUSSION">Urea cycle disorders are part of innate errors in ammonia detoxification or arginine synthesis, secondary to defects in the enzymes involved in this cycle. Clinical manifestations are secondary to elevated levels of serum ammonia. The treatment is composed of an acute and chronic phase.</AbstractText>
      <AbstractText label="CONCLUSIONS"/>
    </Abstract>
    <CopyrightInformation>Creative Commons CC-BY 4.0</CopyrightInformation>
    <ObjectList>
      <Object Type="keyword">
        <Param Name="value">urea</Param>
      </Object>
      <Object Type="keyword">
        <Param Name="value">hyperammonemia</Param>
      </Object>
      <Object Type="keyword">
        <Param Name="value">seizure</Param>
      </Object>
    </ObjectList>
  </Article>
</ArticleSet>