Cómo citar: Campo-Arias A, Daza-Fragozo R, Caballero-Dominguez C. Factores asociados a consumo de cocaína en
estudiantes en Santa Marta, Colombia. Ciencia e Innovación en Salud. 2021. e113: 029-038 DOI 10.17081/innosa.113
Factors associated with cocaine smoking in students at Santa Marta,
Colombia
Factores asociados a consumo de cocaína en estudiantes en Santa Marta,
Colombia
Adalberto Campo-Arias
1
, Remedios Milagros Daza-Fragozo
1
,Carmen Cecilia Caballero-Domíngez
1
*
1
Universidad de Magdalena, Santa Marta, Colombia
*Dirigir correspondencia a: acampoa@unimagdalena.edu.co
ABSTRACT
Background: Cocaine smoking is in the second place of illegal substance use among
Colombian adolescents; however, there is little information about its associated
factors. Methods: A cross-sectional study was designed for which participated in high-
school students between 13 and 17 years. Crude and adjusted associations were
calculated for cocaine smoking. Results: A group of 1,462 adolescent students
(M=14.4 years, SD=0.8) participated in the research, 60.3% were females, and 55.3%
studied in the tenth grade. A total of 40 students (2.7%) reported lifetime cocaine
smoking. Cocaine smoking was associated with lifetime cannabis smoking (OR=8.34,
95%CI 3.70-18.80), lifetime cigarette smoking (OR=7.96, 95%CI 2.96-21.43), risk of
post-traumatic stress disorder (OR=2.43, 95%CI 1.20-4.95), and studying in the tenth
grade (OR=2.38, 95%CI 1.14-4.98). Conclusions: Cannabis and cigarette smoking
are the main variables associated with lifetime cocaine smoking among high-school
adolescents from Santa Marta, Colombia. It is necessary to explore other factors
associated with cocaine smoking in adolescent students
Keywords: Cocaine smoking; risk factors; adolescents; students; cross-sectional
studies.
Article History
I. INTRODUCTION
In the global context, abuse and dependence on legal and illegal
substances represent a problem determined by the state of health, family
relationships, academic or work performance, citizen coexistence, and
the countries' economy (1). Substance use, abuse, and dependence
have grown gradually in recent decades (2). Usually, the consumption of
legal and illegal substances begins in adolescence or the first years of
adult life (3).
About the lifetime prevalence of cocaine smoking among adolescence,
the 2015 National Mental Health Survey omitted the information on the
prevalence of consumption of this illegal substance (4). However, some
studies show that cocaine smoking is in the second place of illegal
substance use in Colombian adolescents, after cannabis smoking, and
its lifetime prevalence varies between 1.4 and 6.6% (5-7).
DOI 10.17081/innosa.113
©Copyright2021.
Campo-Arias
1
et al.
Received: 30 08 20
Accepted: 17 12 20
Published:15 02 21
30
Like other substances, the initiation and maintenance of cocaine smoking is a complex issue
related to several personal and contextual biological and environmental factors (1, 3). Some
factors include a) biological and individual factors such as age, gender, general health condition,
and b) contextual variables such as family environment, exposure to violence, symptoms or
depressive disorders, and consumption of legal substances and other substances illegal like
cannabis (1-3, 8).
Cocaine smoking is a significant concern because it produces symptoms that can be fatal during
poisoning, such as changes in heart rate and blood pressure, cardiac arrhythmias, respiratory
depression, confusion, and seizures (9). Besides, cocaine smoking is frequently associated with
health risk behaviors, for instance, unprotected sex (10), and criminal acts or transgressions of
different levels of social impact, such as fighting or robbery, either as a strategy to get the money
to buy to maintain or to the cognitive changes associated with consumption (11).
Therefore, preventive strategies and early identification of cocaine smoking in adolescents in the
school context are highly relevant in public health (12). This study explores a set of variables
previously omitted from previous research concerning cocaine smoking in adolescent students
in the Colombian Caribbean.
The present study's objective was to explore some factors associated with lifetime cocaine
smoking among high-school adolescents at Santa Marta, Colombia.
II. METHODS
2.1. Study design
An observational, analytical, cross-sectional study was carried out.
2.2. Population, and sample size and protocol
For the sample calculation, it was considered that for the year 2016, 10,810 students were
enrolled in high school grades in Santa Marta, public and private institutions. A multistage
probabilistic cluster sampling was designed. Each classroom was taken as a conglomerate,
and each one would be made up of 25 students on average. Given expected frequencies of
different measured variables, the appropriate sample size was calculated for frequencies as
low as 1% (margin of error of 1) and as high as 50% (margin of error of 5), with a confidence
level of 95%. A sample of 384 participants was acceptable (13). However, the authors preferred
to multiply the initial estimate by four to facilitate the estimation of associations with narrower
confidence intervals. Likewise, the replacement of 25% was included considering the possible
loss of participants, for example, due to the institution's refusal, not having the informed tutor
consent, nor students assent. With the descriptive parameters, the participation of 1,948
students was requested. Only tenth and eleventh-grade students aged between 13 and 17
years were included. Students with a disability to independently complete the questionnaire
were excluded.
31
2.3. Measurements
The research questionnaire asked for demographic variables such as age, gender, education
level, and socioeconomic status. The ages were categorized into two groups, the first being
between 13 and 15 years old and the second between 16 and 17. Likewise, it was investigated
the last-month self-perception of academic performance, perception of general health, family
functioning, risk of post-traumatic stress disorder, risk of a major depressive episode (MDE),
and lifetime school bullying, alcohol drinking, cigarette smoking, cannabis consumption, and
cocaine smoking.
The self-perception of academic performance and perception of general health were evaluated
with a single item taken from the Questionnaire of Epidemiological Surveillance of Psychoactive
Substances, VESPA, widely used in Colombia (14). These items have an excellent, good, fair,
and poor ordinal response pattern. For this analysis, the four response options were
dichotomized into excellent-good and fair-poor.
Lifetime school bullying and substance use (alcohol, cigarette, cannabis, and cocaine) were
assessed with items taken from the Youth Risk Behavior Survey Questionnaire for Middle-
school students of the United States Center for Disease Control. These items have a simple
response pattern, yes or no (15). The Youth Risk Behavior Survey Questionnaire has shown
high reproducibility in previous studies (16).
Family functioning was quantified with the family APGAR. The family APGAR has five items
that measure adaptability, cooperation, growth, affectivity, and resolving capacity. Each item
presents five response options: never, seldom, sometimes, almost always, and always. Such
responses are rated in ascending order from zero to four. Thus, the total scores are observed
between zero and twenty (17). In the present investigation, those scores between 0 and 15
were categorized as family dysfunction. This instrument showed high internal consistency in
the Colombian adolescents' group, Cronbach's alpha of 0.79 (18). In this sample of students,
the family APGAR presented Cronbach's alpha of 0.82.
The risk of post-traumatic stress disorder (PTSD) was measured with the short, four-item
version of the Brief Davidson Trauma Scale (BDTS). This instrument explores the presence of
hyper-alertness, physiological excitement, anger, and mental dullness of post-traumatic stress
disorder. Each item offers four possible responses to which one to four points are assigned.
Consequently, the total scores are in the range between 4 and 16. In the current investigation,
those scores greater than 12 were categorized as high risk of PTSD (19). The large version of
the scale presented acceptable consistency in a previous study with Colombian adults, with
Cronbach's alpha 0.97 (20). In the sample of the present study, Cronbach's alpha was 0.66.
The risk of an MDE was established with the application of the Well-Being Index (WHO-5). This
index quantifies general well-being or the absence of depressive symptoms during the last two
(21). The WHO-5 brings together five items that address mood, tranquility, energy level, quality
of sleep, and daily life enjoyment. Each item presents four options that are rated from one to
four. Total scores are between five and twenty. For the current research, scores lower than nine
were categorized as the risk of an MDE. The WHO-5 showed Cronbach's alpha of 0.70 in
32
another study in adolescents from the Colombian Caribbean (22). In the current sample,
Cronbach’s alpha was 0.82.
2.4. Procedure
The collection of information began with presenting the research objectives, delivering the self-
administered questionnaire to the students who brought the informed consent, previously sent
to the students' parents or legal guardians. In the classroom, the students who agreed to
participate complete the research questionnaire supervised by a field team member. The
participation was utterly anonymous. Data collection was carried out between September and
October 2018.
2.5. Analysis of data
The descriptive component explored frequencies, percentages, mean (M), and standard
deviation (SD). To establish the association between independent variables and lifetime
cocaine smoking was computed odds ratios (OR) with 95% confidence intervals (95%CI).
Those variables that showed probability values less than 25% were considered for the final
adjustment. The goodness of fit was calculated with the Hosmer-Lemeshow’s test for the
adjusted variables. Those that showed 95%CI that did not include the unit were accepted as
significant associations. The analysis was completed in IBM-SPSS, version 23.0.
2.6. Ethical issues
This investigation included the review and approval of a Research Ethics Committee in Santa
Marta, Colombia. Parents signed informed consent and students assent to participate.
III. RESULTS
3.1. Sample description
A total of 1,462 students participated in the research. Four-hundred eighty-six students than
expected (24.9%) participated because several selected schools refused to participate, the
classrooms had fewer students than the estimated average, or the students did not bring
informed consent from their parents. The ages were observed between 13 and 17 years,
M=14.4 years (SD=0.8). The frequencies and percentages for each variable are shown in Table
1. Regarding lifetime cocaine smoking, 40 students (2.7%) answered affirmatively, and 1,442
(97.3%) denied having ever used it in their life.
3.2. Crude and adjusted association
Statistically significant associations with cocaine smoking were observed between health
perception, risk of PTSD, risk of MDE, and lifetime consumption of alcohol, cigarette, and
cannabis. See table 2.
33
Table 1. Characteristics of the students.
Variable
Frequency
Age (years)
Between 13 and 15
Between 16 and 17
425
1,037
Gender
Female
Male
882
580
Grade
Tenth
Eleventh
809
653
Income
Low
Middle-high
Did not answer
725
557
190
Academic achievement
Excellent-good
Fair-poor
1,012
450
Health condition
Excellent-good
Fair-poor
1,101
361
Family dysfunction
Yes
No
1,112
350
Risk of post-traumatic stress disorder
Yes
No
283
1,179
Risk of a major depressive episode
Yes
No
446
1,016
School bullying
Yes
No
336
1,126
Lifetime alcohol drinking
Yes
No
330
1,132
Lifetime cigarette smoking
Yes
No
328
1,134
Lifetime cannabis smoking
Yes
No
170
1,292
Source: It was prepared by the authors from the data collected.
34
Table 2. Factors associated with lifetime cocaine smoking in students from Santa Marta,
Colombia
Variable
OR
CI95%
Age 13-15 years
1.05
0.53-2.08
Female gender
1.55
0.78-3.08
Tenth grade
1.92
0.97-3.80
Low income*
1.04
0.73-1.48
Fair-poor academic achievement
1.88
0.99-3.53
Fair-poor health condition
2.32
1.22-4.38
Family dysfunction
0.94
0.46-1.95
Risk of post-traumatic stress disorder
3.21
1.69-6.10
Risk of a major depressive episode
2.34
1.25-4.39
School bullying
1.64
0.84-3.21
Lifetime alcohol drinking
5.70
1.37-23.74
Lifetime cigarette smoking
21.74
9.04-52.28
Lifetime cannabis use
23.95
11.71-48.99
* Compared to middle-high, not including missing data.
Source: It was prepared by the authors from the data collected.
For the final adjustment, grade and self-perception of academic performance that showed
probability values of less than 25% were considered. The best-fitting model showed descending
order that cannabis use, cigarette smoking, risk of PTSD, and studying in the tenth grade were
significantly associated with lifetime cocaine smoking. See table 3.
Table 3. Adjusted model for factors associated with cocaine smoking in high-school students
from Santa Marta, Colombia
Variable
OR
CI95%
Lifetime cannabis smoking
8.34
3.70-18.80
Lifetime cigarette smoking
7.96
2.96-21.43
Risk of post-traumatic stress disorder
2.43
1.20-4.95
Tenth grade
2.38
1.14-4.98
Hosmer-Lemeshow test=4.07, df=4, p=0.40.
Source: It was prepared by the authors from the data collected.
IV. DISCUSSION
In the present study, it is observed that lifetime cigarette and cannabis smoking, risk of PTSD,
and studying tenth grade were significantly associated with lifetime cocaine smoking among
high-school adolescents in Santa Marta, Colombia.
The association between the level of schooling and cocaine smoking has not been observed in
previous studies. However, Espinosa et al. (15) and Manrique-Abril et al. (23) did not observe
statistically significant differences between the tenth and eleventh-grade students from Cali and
Tunja, Colombia. Likewise, Maldonado et al. (24) found a similar prevalence of cocaine
smoking in students of the last two years of high school in Lima, Peru.
35
In the present analysis, it was shown that the risk of PTSD was associated with cocaine
smoking. This finding is consistent with studies in other countries. For example, Flores et al.
(25), in Mexican American adolescents, observed that they experienced marked symptoms of
PTSD correlated with the consumption of illegal substances, cannabis, and cocaine, among
others. Similarly, Schiff et al. (26), in Arab and Jewish middle-school adolescents, observed
that scores for post-traumatic stress were associated with cannabis use and ecstasy during the
last year.
In the current study, cigarette smoking was related to cocaine smoking. Similar to the
association observed by Cogollo et al. (8), these researchers showed that current smoking
increased the frequency of consumption of illicit substances in Colombian adolescents, and
Céline et al. (27) reported that lifetime cigarette smoking was associated with cocaine smoking
in French adolescents. In the same sense, longitudinal studies showed a similar association.
Keyes et al. (28), in the United States in high-school students, observed that the prevalence of
cigarette smoking in eighth and tenth grades was associated with the prevalence of cocaine
smoking in twelfth grade. Nkansah-Amankra (29) showed that lifetime cigarette smoking in
early adolescence predicted (between 1 and 19 times) cocaine smoking in late adolescence in
middle- and high-school students in the United States. However, do Nascimento et al. (30)
reported independence between tobacco and lifetime cocaine smoking in adolescent students
at Penabumco, Brazil.
In the present analysis, it was observed that cannabis use was associated with cocaine
smoking. This observation is consistent with Céline et al. (27), who found that cannabis smoking
was significantly associated with lifetime cocaine smoking. However, Nkansah-Amankra (29),
in the study mentioned above, observed that lifetime cannabis smoking in early adolescence
did not predict cocaine smoking in late adolescence.
The similarities and differences observed in this study's findings with the previous studies may
lie in the study designs, cross-sectional and longitudinal, the disparities in the social and cultural
contexts, the form of measurement of the variables of interest, and the years of carrying out the
studies. It is essential to unify criteria for the measurement and monitoring of substance use in
adolescents and adults. This strategy would allow better comparisons and interpretation of the
findings in the different contexts (31). Convoluted health problems such as cocaine smoking
require permanent reviews of the prevalence and associated variables according to the
determinants of health for each community; the findings of particular contexts can be rarely
generalized to the world population, beyond the world increasingly globalized (2).
The prevention of cocaine smoking requires comprehensive and integrated strategies and
actions (12). Cocaine smoking is a problem in which converges individual, medial and structural
determinants (1-3). However, professionals must pay particular attention to the prevention of
legal substance use such as alcohol and cigarettes, which often serve as a gateway to illegal
substances such as cannabis and cocaine; it is a phenomenon of escalating consumption. It is
common since legal to illegal substances or those of lesser potency to higher potency in the
effect or possibility of inducing dependency (29). In the present study, specific cultural variables
that qualify substance use in adolescents, such as sexist cultural patterns or familism, were not
quantified. Measurement of these cultural variables has increased in epidemiological studies;
36
however, the difficulty of objectifying the evaluation of collective attitudes, beliefs, and practices
(2).
The current study contributes to knowledge because presenting the variables associated
exclusively with lifetime cocaine smoking due to the low prevalence in previous studies, and
they had not been analyzed in a disaggregated way of other illegal substances. However, this
research has the limitation of cross-sectional studies that prevent establishing the association's
direction unequivocally. Besides, the number of students who reported cocaine smoking at
some time in their lives was low, and, therefore, they are observed wide confidence intervals in
some associations. There is a risk of type II error for other explored associations (13).
V. CONCLUSIONS
It is concluded that lifetime cigarette and cannabis smoking, the risk of PTSD, and the tenth
grade are associated with lifetime cocaine smoking among high-school adolescents at Santa
Marta, Colombia. It is necessary to know how to explore other factors associated with cocaine
smoking in middle school students.
Author contribution: Adalberto Campo-Arias: Conceptualization, content and data curation,
formal data analysis, acquisition of funds, research, methodology, project management,
material resources, software, supervision, visualization, and revision and editing. Remedios
Milagros Daza-Fragozo: Conceptualization, content and data curation, software, visualization,
draft writing, and revision and editing. Carmen Cecilia Caballero-Domínguez:
Conceptualization, acquisition of funds, research, supervision, validation, visualization, and
revision and editing.
Funding: The Research Vice-Rectory of the University of Magdalena financed this work
through Resolution 0347 of 2018 (Fonciencias Call for Proposals 2017).
Acknowledgments: Our gratitude for the invaluable cooperation in the process of collecting
information for the research assistant psychology students: Adriana Rodríguez Martínez, Ana
Celis Márquez, Carlos Fuentes López, Daniela Gonzales Cantillo, Heiner Tordecilla Arroyo,
Nataly Tapia Duarte, Sandra Gómez Mariscal, and Yuleinys Dávila Gómez. Also, we want to
thank to the support psychology professionals: Amparo Echeverry Arias, Heigui Araújo ñiga,
Johana Guerrero Bolaño, and María Paola Jiménez Villamizar.
Conflict of interest: Nothing to declare.
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