Vitiligo, estrés psicológico y bioquímica del cerebro: Una revisión sistemática desde la neurociencia
Vitiligo, psychological stress and biochemistry of the brain: A systematic review from neuroscience
DOI:
https://doi.org/10.17081/psico.26.50.6399Palabras clave:
vitíligo, estrés psicológico, bioquímica, enfermedad autoinmune, estrés oxidativoResumen
Objetivo: El propósito de este estudio es establecer los mecanismos de la actividad Bioquímica a través del Estrés Psicológico que influyen en la enfermedad del vitiligo desde una perspectiva neurocientifica, mediante una revisión sistemática de la literatura de los últimos 5 años.
Método: La búsqueda sistemática se llevó a cabo en las bases de datos Scopus, PubMed y Web of Science para identificar los estudios que describan la enfermedad de Vitiligo, el estrés psicológico y la bioquímica del cerebro, se establecieron criterios de inclusión y exclusión para la selección de los artículos, así mismo, se evaluó su calidad y pertinencia.
Resultados: La revisión sistemática arrojó 15.503 artículos, 70 fueron preseleccionados de acuerdo a lo informado en el resumen y validados para lectura completa. Para la síntesis narrativa se utilizaron 23 artículos científicos.
Conclusión: La enfermedad de vitiligo guarda una estrecha relación con el estrés psicológico y está acompañado de un desequilibrio bioquímico que conduce a un proceso inflamatorio y destructivo de los melanocitos de la piel.
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Al-Sadi, A. M., Al-Oweisi, F. A., Edwards, S. G., Al-Nadabi, H., & Al-Fahdi, A. M. (2015). Genetic analysis reveals diversity and genetic relationship among Trichoderma isolates from potting media, cultivated soil and uncultivated soil. BMC Microbiology, 15(1), 1–11. https://doi.org/10.1186/S12866-015-0483-8/FIGURES/4
Banerjee, N., Gayen, S., Modak, D., Sarkar, S., Saha, B., & Mukhopadhyay, S. (2019). Systemic Redox Imbalance Along with Increased Serum Sialic Acid is Prevalent in Patients with Active Vitiligo: A Study from a Tertiary Care Teaching Hospital of Eastern India. Indian Journal of Dermatology, 64(2), 97. https://doi.org/10.4103/IJD.IJD_448_17
Bergqvist, C., & Ezzedine, K. (2020). Vitiligo: A Review. Dermatology, 236(6), 571–592. https://doi.org/10.1159/000506103
Boza, J. C., Giongo, N., MacHado, P., Horn, R., Fabbrin, A., & Cestari, T. (2016). Quality of Life Impairment in Children and Adults with Vitiligo: A Cross-Sectional Study Based on Dermatology-Specific and Disease-Specific Quality of Life Instruments. Dermatology, 232(5), 619–625. https://doi.org/10.1159/000448656
Cupertino, F., Niemeyer-Corbellini, J. P., & Ramos-e-Silva, M. (2017). Psychosomatic aspects of vitiligo. Clinics in Dermatology, 35(3), 292–297. https://doi.org/10.1016/J.CLINDERMATOL.2017.01.001
Dabas, G., Vinay, K., Parsad, D., Kumar, A., & Kumaran, M. S. (2020). Psychological disturbances in patients with pigmentary disorders: a cross-sectional study. Journal of the European Academy of Dermatology and Venereology, 34(2), 392–399. https://doi.org/10.1111/JDV.15987
Dai, Y. X., Tai, Y. H., Chang, Y. T., Chen, T. J., & Chen, M. H. (2021). Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases: A Nationwide Population-Based Cohort Study. Psychosomatic Medicine, 83(3), 212–217. https://doi.org/10.1097/PSY.0000000000000920
Do Bú, E. A., Santos, V. M. dos, Lima, K. S., Pereira, C. R., Alexandre, M. E. S. de, & Bezerra, V. A. dos S. (2022). Neuroticism, stress, and rumination in anxiety and depression of people with Vitiligo: An explanatory model. Acta Psychologica, 227, 103613. https://doi.org/10.1016/J.ACTPSY.2022.103613
DeAngelis, R. T., & Taylor, J. (2020). Parental Status and Biological Functioning: Findings from the Nashville Stress and Health Study. Population Research and Policy Review, 39(2), 365-373. https://doi.org/10.1007/s11113-019-09534-1
Fang, W., Tang, L., Wang, G., Lin, J., Liao, W., Pan, W., & Xu, J. (2020). Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling. Journal of Investigative Dermatology, 140(11), 2230-2241.e9. https://doi.org/10.1016/J.JID.2019.03.1165
Gürpinar, A., Doğan Günaydin, S., Kiliç, C., & Karaduman, A. (2019). Association of serum cortisol and dehydroepiandrosterone sulfate (DHEAS) levels with psychological stress in patients with vitiligo. Turkish Journal of Medical Sciences, 49(3), 832–837. https://doi.org/10.3906/sag-1812-84
Guidi, J., Lucente, M., Sonino, N., & Fava, G. A. (2020). Allostatic Load and Its Impact on Health: A Systematic Review. Psychotherapy and Psychosomatics, 90(1), 11-27. https://doi.org/10.1159/000510696
Hamidizadeh, N., Ranjbar, S., Ghanizadeh, A., Parvizi, M. M., Jafari, P., & Handjani, F. (2020). Evaluating prevalence of depression, anxiety and hopelessness in patients with Vitiligo on an Iranian population. Health and Quality of Life Outcomes, 18(1), 1–7. https://doi.org/10.1186/S12955-020-1278-7/TABLES/6
Henning, S. W., Jaishankar, D., Barse, L. W., Dellacecca, E. R., Lancki, N., Webb, K., Janusek, L., Mathews, H. L., Price, R. N., & Caroline Le Poole, I. (2020). The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data. PLOS ONE, 15(1), e0227909. https://doi.org/10.1371/JOURNAL.PONE.0227909
Kawakami, T., & Hashimoto, T. (2011). Disease severity indexes and treatment evaluation criteria in vitiligo. Dermatology Research and Practice, 2011. https://doi.org/10.1155/2011/750342
Kotb El-Sayed, M. I., Abd El-Ghany, A. A., & Mohamed, R. R. (2018). Neural and endocrinal pathobiochemistry of vitiligo: comparative study for a hypothesized mechanism. Frontiers in endocrinology, 9, 197. https://doi.org/10.3389/fendo.2018.00197
Krüger, C., & Schallreuter, K. U. (2012). A review of the worldwide prevalence of vitiligo in children/adolescents and adults. International Journal of Dermatology, 51(10), 1206–1212.
https://doi.org/10.1111/J.1365-4632.2011.05377.X
Kussainova, A., Kassym, L., Akhmetova, A., Dvoryankova, E., Glushkova, N., Khismetova, Z., Adilgozhina, S., Tuleutayeva, R., Kaskabayeva, A., Massabayeva, M., Pak, L., & Semenova, Y. (2022). Associations between serum levels of brain-derived neurotrophic factor, corticotropin releasing hormone and mental distress in vitiligo patients. Scientific Reports 2022 12:1, 12(1), 1–8. https://doi.org/10.1038/s41598-022-11028-8
K
ussainova, A., Kassym, L., Akhmetova, A., Glushkova, N., Sabirov, U., Adilgozhina, S., Tuleutayeva, R., & Semenova, Y. (2020). Vitiligo and anxiety: A systematic review and meta-analysis. PLOS ONE, 15(11), e0241445. https://doi.org/10.1371/JOURNAL.PONE.0241445
Lacerda, K. A. P., Silva, L. A., Mendonca, G. S., Guimarães, R. A., & Guilo, L. A. (2020). Association between quality of life and perceived stress in patients with vitiligo: case control study. Biosci. j. (Online), 36(3), 1032–1042. https://doi.org/10.14393/BJ-V36N3A2020-45105
Lai, Y. C., Yew, Y. W., Kennedy, C., & Schwartz, R. A. (2017). Vitiligo and depression: A systematic review and meta‐analysis of observational studies. British Journal of Dermatology, 177(3), 708-718. https://doi.org/10.1111/bjd.15199
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2018). Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation. Molecular Neurobiology 2018 56:5, 56(5), 3295–3312. https://doi.org/10.1007/S12035-018-1283-6
Liu, J. W., Tan, Y., Chen, T., Liu, W., Qian, Y. T., & Ma, D. L. (2022). Post-Traumatic Stress in Vitiligo Patients: A Neglected but Real-Existing Psychological Impairment. Clinical, Cosmetic and Investigational Dermatology, 15, 373. https://doi.org/10.2147/CCID.S350000
LVineetha, M., & Palakkal, S. (2020). Comparison of Serum Malondialdehyde Levels in Vitiligo Patients and Healthy Controls. Journal of Evolution of Medical and Dental Sciences, 9(6), 343–347. https://go.gale.com/ps/i.do?p=AONE&sw=w&issn=22784748&v=2.1&it=r&id=GALE%7CA619548860&sid=googleScholar&linkaccess=fulltext
McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: central role of the brain. Physiological reviews, 87(3), 873-904. https://doi.org/10.1152/physrev.00041.2006
Mangini, C. S. M., Vasconcelos, R. C. F. de, Rodriguez, E. V. R., & Oliveira, I. R. L. de. (2022). Social isolation: main dermatosis and the impact of stress during the COVID-19 pandemic. Einstein (São Paulo), 20, eAO6320. https://doi.org/10.31744/EINSTEIN_JOURNAL/2022AO6320
Mason, C. P., & Gawkrodger, D. J. (2005). Vitiligo presentation in adults. Clinical and Experimental Dermatology, 30(4), 344–345. https://doi.org/10.1111/J.1365-2230.2005.01779.X
Mathachan, S. R., Khurana, A., Gautam, R. K., Kulhari, A., Sharma, L., & Sardana, K. (2021). Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study. Journal of Cosmetic Dermatology, 20(1), 352–359.https://doi.org/10.1111/JOCD.13499
Mirnezami, M., dermatology, H. R.-I. journal of, & 2018, undefined. (n.d.). Serum zinc level in vitiligo: A case-control study. Ncbi.Nlm.Nih.Gov. Retrieved November 12, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996627/
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & and the PRISMA Group. (2009). Reprint—Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Physical Therapy, 89(9), 873-880. https://doi.org/10.1093/ptj/89.9.873
Namazi, M. R., Nozari, F., & Jafari, P. (2019). Serum magnesium concentrations in vitiligo patients. Magnesium Research, 32(2), 51–53. https://doi.org/10.1684/MRH.2019.0450
Nasser, M. A. E. M., Raggi El Tahlawi, S. M., Abdelfatah, Z. A., & Soltan, M. R. (2021). Stress, anxiety, and depression in patients with vitiligo. Middle East Current Psychiatry, 28(1), 1–10. https://doi.org/10.1186/S43045-021-00120-W/TABLES/5
Nazar, I., Kamran, F., & Masood, A. (2021). Psychosocial Predictors of Quality of Life in Patients With Vitiligo. Pakistan Journal of Psychological Research, 36, 19-36.
https://doi.org/10.33824/PJPR.2021.36.1.02
Ozcan, Y., Karagün, E., & Alpay, M. (2022a). Decreased oxidative stress markers in patients with active and generalized vitiligo. Konuralp Tıp Dergisi, 14(2), 317–322. https://doi.org/10.18521/KTD.880577
Öztekin, A., & Öztekin, C. (2020). Sleep Quality and Depression in Vitiligo Patients. Eurasian Journal of Family Medicine, 9(1), 35-41. https://doi.org/10.33880/ejfm.2020090105
Sarhan, D., Mohammed, G. F. A., Gomaa, A. H. A., & Eyada, M. M. K. (2015). Female Genital Dialogues: Female Genital Self-Image, Sexual Dysfunction, and Quality of Life in Patients With Vitiligo With and Without Genital Affection, 42(3), 267–276. https://doi.org/10.1080
Savaş Erdoğan, S., Falay Gür, T., & Doğan, B. (2021). Anxiety and depression in pediatric patients with vitiligo and alopecia areata and their parents: A cross-sectional controlled study. Journal of Cosmetic Dermatology, 20(7), 2232–2239. https://doi.org/10.1111/JOCD.13807
Schallreuter, K. U., Salem, M. A. E. L., Gibbons, N. C. J., Maitland, D. J., Marsch, E., Elwary, S. M. A., & Healey, A. R. (2012). Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: epidermal H2O2/ONOO–-mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immune response signaling. The FASEB Journal, 26(6), 2471–2485. https://doi.org/10.1096/FJ.11-201897
Silverberg, J. I., & Silverberg, N. B. (2013). Association Between Vitiligo Extent and Distribution and Quality-of-Life Impairment. JAMA Dermatology, 149(2), 159–164. https://doi.org/10.1001/JAMADERMATOL.2013.927
Simons, R. E., Zevy, D. L., & Jafferany, M. (2020). Psychodermatology of vitiligo: Psychological impact and consequences. Dermatologic Therapy, 33(3), e13418. https://doi.org/10.1111/DTH.13418
Sudarsa, P. S. S., Praharsini, I. G. A. A., & Karna, R. V. (2020). Correlation between malondialdehyde levels and disease activity in vitiligo. Bali Medical Journal, 9(3), 676-679. https://doi.org/10.15562/bmj.v9i3.2020
Sterling, P. (2020). What Is Health?: Allostasis and the Evolution of Human Design. MIT Press.
Tang, L., Fang, W., Lin, J., Li, J., Wu, W., & Xu, J. (2018). Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/β-catenin signaling. Laboratory Investigation, 98(12), Article 12. https://doi.org/10.1038/s41374-018-0126-4
Tanwar, S., Thakur, V., Bhatia, A., & Parsad, D. (2022). Catecholamines’ accumulation and their disturbed metabolism at perilesional site: a possible cause of vitiligo progression. Archives of Dermatological Research 2022, 1–8. https://doi.org/10.1007/S00403-022-02333-3
Türkmen, D., & Altunişik, N. (2018). Serum Bilirubin, uric acid and albumin antioxidant levels in patients with vitiligo. Turkiye Klinikleri Dermatoloji, 28(2), 63–68. https://doi.org/10.5336/DERMATO.2018-62710
Urrútia, G., & Bonfilll, X. (2013). La declaración PRISMA: un paso adelante en la mejora de las publicaciones de la Revista Española de Salud Pública. Revista Española de Salud Pública, 87(2), 99-102. https://doi.org/10.4321/S1135-57272013000200001
Oken, B. S., Chamine, I., & Wakeland, W. (2015). A systems approach to stress, stressors and resilience in humans. Behavioural Brain Research, 282, 144-154. https://doi.org/10.1016/j.bbr.2014.12.047
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. International Journal of Surgery, 88, 105906. https://doi.org/10.1016/j.ijsu.2021.105906
Yanik, M. E., Erfan, G., Albayrak, Y., Aydin, M., Kulac, M., & Kuloglu, M. (2014). Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo. Neuropsychiatric Disease and Treatment, 10, 2361. https://doi.org/10.2147/NDT.S74826
Zhang, Y., Cai, Y., Shi, M., Jiang, S., Cui, S., Wu, Y., Gao, X. H., & Chen, H. D. (2016). The Prevalence of Vitiligo: A Meta-Analysis. PLOS ONE, 11(9), e0163806. https://doi.org/10.1371/JOURNAL.PONE.0163806
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