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2020

Copyright (c) 2020 Jhoalmis Sierra-Castrillo, Lyz J. Gómez-Rave, Denny M. Cardenas-Sierra, Nicolás Villán-Bustamante , Nelsy Paola Acosta-León, Valmore Bermúdez-Pirela

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Correlation between levels of thyroid hormones and serum concentration of interleukin 6 (IL-6), C-reactive protein (CRP) and lactate dehydrogenase (LDH), in patients with type 2 diabetes

https://doi.org/10.17081/innosa.77
Jhoalmis Sierra-Castrillo
Universidad de Santander. Bacteriología y Laboratorio clínico. Cúcuta, Colombia
Lyz J. Gómez-Rave
Institución Universitaria Colegio Mayor de Antioquia. Medellín, Colombia
Denny M. Cardenas-Sierra
Universidad de Santander. Bacteriología y Laboratorio clínico. Cúcuta, Colombia
Nicolás Villán-Bustamante
Universidad de Santander. Bacteriología y Laboratorio clínico. Cúcuta, Colombia
Nelsy Paola Acosta-León
Universidad de Santander. Bacteriología y Laboratorio clínico. Cúcuta, Colombia
Valmore Bermúdez-Pirela
Universidad Simón Bolívar. Barranquilla, Colombia
https://orcid.org/0000-0003-1880-8887

Corresponding Author(s) : Jhoalmis Sierra-Castrillo

jhosica1988@hotmail.com

Ciencia e Innovación en Salud, 2020

Abstract

 






Background: Insulin and thyroid hormones have a shared function regulating metabolism, which has led many authors to investigate the relationship between T2D, thyroid disorders and their biochemical mediators. Methods: Based on a cross-sectional, observational cohort model, which included 125 subjects with DM2, who underwent measurements of the analytes using chemical, enzymatic and immunometric tests. Results: 88 patients were found with some type of alteration in the hormonal levels, of them more than 90.9% presented low concentration of fT4 and more than 50% low fT3, in addition an inverse correlation was found between LDH -TSH (p = 0.02) and LDH- Fructosamine (p = 0.01). In the group of unaltered diabetics, a direct correlation was found between LDH-IL-6 (p = 0.01). Conclusions: It is clear that T2D patients are vulnerable to changes in thyroid function. According to the literature, the most common disorder is subclinical hypothyroidism, but according to our results it is possible to include the development of the euthyroid sick syndrome (ESS). The interpretation of the role of PCR, IL-6 and LDH in these processes is still complex. It is suggested to investigate in a more rigorous way the LDH and its association with TSH and IL-6 during T2D





Keywords

Diabetes Mellitus type 2, thyroid hormones, lactate dehydrogenase, interleukin
1.
Sierra-Castrillo J, Gómez-Rave LJ, Cardenas-Sierra DM, Villán-Bustamante N, Acosta-León NP, Bermúdez-Pirela V. Correlation between levels of thyroid hormones and serum concentration of interleukin 6 (IL-6), C-reactive protein (CRP) and lactate dehydrogenase (LDH), in patients with type 2 diabetes. Ciencia e Innovación en Salud [Internet]. 2020 Jun. 20 [cited 2025 Jan. 30];. Available from: https://revistas.unisimon.edu.co/index.php/innovacionsalud/article/view/3999
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