Low High Density Lipoproteins in sepsis: an associated factor with worst prognosis

Abstract

Introduction: Sepsis is a frequent disease that cause a high morbidity and mortality in the adult population that consult to the emergency services, the dysregulated inflammatory response that characterizes it can be modulated by high density lipoprotein levels, thus the objective of this study was to determinate the association between high density lipoprotein levels and complications in patients with sepsis diagnosis. Materials and Methods: An observational, prospective study was carried out with a non-experimental design, whose population were 60 subjects of both genders with sepsis diagnosis. The data was collected using a form that included: identification data, clinical data such as: blood pressure, heart rate, respiratory rate, Glasgow coma scale and laboratory data: leukocytes, HDL-C level, creatinine, total bilirubin, platelets, diuresis, PaO₂/FiO₂, and coagulation profile. Results: Of the total sample, 58.3% (n=35) presented complications such as septic shock or multi-organ failure, with a higher percentage in those with lower HDL-C (HDL-C <30mg/dl: 82.8% vs HDL-C ≥30: 35.5% (χ²=13.78, p<0.01). Similarly, this group required greater use of vasoactive agents (χ²=36.47, p<0.01). While clinical parameters such as systolic blood pressure, Glasgow coma scale, platelets and PaO₂ / FiO₂ showed a lower average in patients with HDL-C <30 mg/dl Conclusion: Serum levels of HDL-C<30 mg/dl were associated with a higher percentage of patients that evolved to septic shock, requirement of vasoactive agents and multi-organ failure.