Late-onset type 1 diabetes mellitus or latent autoimmune diabetes in adults: a teachable moment
DOI:
https://doi.org/10.17081/innosa.93Keywords:
diabetes, adults, autoimmunity, diagnosis, insulin therapyAbstract
Adult-onset autoimmune diabetes (AOAD) is clinical form of diabetes with a wide spectrum of genotypical and phenotypical manifestations, which has risen in prominence in recent decades, probably due to greater interest in its pathogenic mechanisms, and increased identification of autoimmune markers. The clinical presentation may vary from type 1 diabetes mellitus to latent autoimmune diabetes in adults, which although clearly distinct from a theoretical viewpoint, may pose various clinical pitfalls in practice. We present the case of a patient with AOAD which featured several diagnostic challenges during follow-up.
Downloads
References
Hawa MI, et al. Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: action LADA 7. Diabetes Care 2013;36:908–913. DOI: 10.2337/dc12-0931
Hosszúfalusi N, Vatay A, Rajczy K, et al. Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression. Diabetes Care. 2003;26(2):452-7. DOI: 10.2337/diacare.26.2.452
Rojas J, Gonzalez R, Chavez M, et al. Diabetes mellitus tipo 2, historia natural de la enfermedad, y la experiencia en el Centro de Investigaciones Endocrino Metabólicas “Dr. Félix Gómez”. Diabetes Internacional. 2013;V(1): 13-26. http://saber.ucv.ve/ojs/index.php/rev_di/article/view/9345
Zayed H. Epidemiology of diabetic ketoacidosis in Arab patients with type 1 diabetes: a systematic review. Int J Clin Pract. 2016;70(3):186-95. DOI: 10.1111/ijcp.12777
Paschou SA, Papadopoulou-Marketou N, Chrousos G, et al. On type 1 diabetes mellitus pathogenesis. Endocr Connect. 2018; 7(1): R38–R46. DOI: 10.1530/EC-17-0347
Espino-Paisan L, Urcelay E, Gómez E, Santiago JL. Early and Late Onset Type 1 Diabetes: One and the Same or Two Distinct Genetic Entities? (November 25th 2011). Type 1 Diabetes Complications, David Wagner, IntechOpen, DOI: 10.5772/23706
Barker A, Lauria A, Schloot N, et al. Age-dependent decline of β‑cell function in type 1 diabetes after diagnosis: a multicenter longitudinal study. Diabetes Obes. Metab. 2014;16: 262–267. DOI: 10.1111/dom.12216
Buzzeti R, Zampetti S, Maddaloni E. Adult-onset autoimmune diabetes: current knowledge and implications for management. Nat Rev Endocrinol. 2017;13(11):674-686. DOI: 10.1038/nrendo.2017.99
Wensveen FM, Šestan M, Turk Wensveen T, Polić B. 'Beauty and the beast' in infection: How immune-endocrine interactions regulate systemic metabolism in the context of infection. Eur J Immunol. 2019;49(7):982-995. DOI: 10.1002/eji.201847895
Bermudez V, Aparicio D, Peñaranda L, et al. Diabetes Autoinmune Latente del Adulto (Diabetes LADA): A propósito de un caso. Diabetes Internacional. 2009;I(1):5-8. http://saber.ucv.ve/ojs/index.php/rev_di/article/view/1897
Tanaka S, Ohmori M, Awata T, et al. Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society. Diabetol Int. 2015;6(1):1–7. DOI: 10.1007/s13340-014-0199-2
Sokołowska M, Chobot A, Jarosz-Chobot P. The honeymoon phase - what we know today about the factors
that can modulate the remission period in type 1 diabetes. Pediatr Endocrinol Diabetes Metab. 2016;22(2):66-70. DOI: 10.18544/PEDM-22.02.0053
Zhong T, Tang R, Gong S, et al. The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno-metabolic mechanisms. Diabetes Metab Res Rev. 2020;36(2):e3207. DOI: 10.1002/dmrr.3207
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Isabel Borges, Roberto Añez, Mervin Chavez-Castillo, Juan Salazar
This work is licensed under a Creative Commons Attribution 4.0 International License.
