Issue

2020

Copyright (c) 2020 Estevan Marin, Noraima Chirinos , Néstor Galban, Bermary Garrido, Yosselin Gómez , Aida Souki, Clímaco Cano, Juan Salazar, Carmem Prieto

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Link between oxidative stress and hemolytic anemia: A molecular vision

https://doi.org/10.17081/innosa.91
Estevan Marin
Universidad de Zulia. Maracaibo, Venezuela; Research Division, DBSS, 110861 Bogotá, Colombia
https://orcid.org/0000-0001-6137-8291
Noraima Chirinos
Universidad de Zulia. Maracaibo, Venezuela
Néstor Galban
Universidad de Zulia. Maracaibo, Venezuela
Bermary Garrido
Universidad de Zulia. Maracaibo, Venezuela
Yosselin Gómez
Universidad de Zulia. Maracaibo, Venezuela
Aida Souki
Universidad de Zulia. Maracaibo, Venezuela
Clímaco Cano
Universidad de Zulia. Maracaibo, Venezuela
Juan Salazar
Universidad de Zulia. Maracaibo, Venezuela
Carmem Prieto
Universidad de Zulia. Maracaibo, Venezuela; Universidad Católica de Cuenca, Cuenca, Ecuador

Corresponding Author(s) : Estevan Marin

maringarciae@gmail.com

Ciencia e Innovación en Salud, 2020

Abstract

Hemolytic anemias are a group of diseases that cause reduction of hemoglobin concentration in blood as a result of the destruction of erythrocytes. According to the etiological causes, hemolytic anemias can be separated in hereditary and acquired. Over the last years, there have been an increase of evidence that points the association of oxidative stress and hemolytic anemias such as glucose-6-phosphate dehydrogenase deficiency, sickle cell disease, thalassemias, autoimmune hemolytic anemia, paroxysmal nocturnal hemoglobinuria and drug-induced hemolytic anemia. In conjunction, it has been suggested that antioxidant therapy may work as potential complementary treatment in some of these hematologic diseases. Therefore, the objective of this narrative revision in describing concisely the mechanism of how oxidative stress is produced in erythrocytes, its involvement in hemolytic anemias and lastly the outcome of antioxidant therapy in the treatment of these diseases.

Keywords

hemolytic anemia, red blood cell, hemolysis, oxidative stress, free radicals
1.
Marin E, Chirinos N, Galban N, Garrido B, Gómez Y, Souki A, Cano C, Salazar J, Prieto C. Link between oxidative stress and hemolytic anemia: A molecular vision. Ciencia e Innovación en Salud [Internet]. 2020 Oct. 6 [cited 2024 Nov. 25];. Available from: https://revistas.unisimon.edu.co/index.php/innovacionsalud/article/view/4271
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